Natural polymer research has recently become the focus of intensive research in the quest for new enabling excipients for novel\ndrugs in pharmaceutical formulation for optimal treatment outcomes. Evaluations of some excipients have shown deleterious\nhaematological effects of varying extents on the safety profile of these excipients. A 90-day subchronic toxicity study was conducted\nto evaluate the influence of cocoa pod husk (CPH) pectin on indicators for haematotoxicity. Male and female Sprague Dawley rats\n(SDRs) were fed with CPH pectin in doses up to 71.4 mg/kg. The effects of CPH pectin on the haematological indices, direct and\ntotal bilirubin, and the spleen were determined.The results indicated that CPH pectin did not induce any untoward toxic effects\non the haematological indices, bilirubin levels, and the spleen. There were, however, elevations in MCV at day 30, which was not\nsustained after the 90 days. The data obtained from this study did not reveal any remarkable findings of toxicological relevance to\nthe haematopoietic system.
Loading....